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Mitochondrial and Cardiovascular Physiopathology | UMR Inserm U1083 - CNRS 6015

MitoLab - Mitochondrial PathophysiologyDirector G. Lenaers

MitoLab is born from the convergence of mitochondrial physiology enthusiasts and the challenges raised by hereditary and common diseases involving mitochondrial dysfunction

Created 20 years ago with the clinic and molecular diagnostic of hereditary mitochondrial pathologies, our expertise and technologic skills have improved with the aim to build a continuum of researches "bed to bed”, and the perspective to infer new rational and efficient treatments for patients.

Three fundamental strategic and thematic orientations developed :

  1. mitochondrial dynamics,
  2. maintaining the integrity of the mitochondrial genome,
  3. the metabolism of the mitochondria

With hereditary and common associated  diseases:

  1. Dominant optic atrophy, Charcot Marie Tooth disease, encephalopathies, and myopathies, myocardial infarction, arterial hypertension,
  2. Mitochondrial DNA depletion syndromes, progressive external ophthalmoplegia and ovarian failure, intrauterine growth retardation,
  3. Leber Optic Neuropathy, MELAS, Leigh Syndrome and Glaucoma, DMLA, Myopia, Thyroid and Kidney Cancer, Sickle Cell Disease, Endometriosis, Forensic medicine.

MitoLab is a team located at the interface between the University and the University Hospital Center of Angers, bringing together about fifty researchers, lecturer-researchers, doctors, engineers and technicians, post-doctoral and PhD students, Master students and internal in medicine.

The team involves the services of Biochemistry and Molecular Biology, Genetics, Ophthalmology Neurology, Urology and Reproductive Biology.

It also interacts with the services of Gynecology-Obstetrics, Pediatrics, Internal and Forensic Medicine, Cardiology, Endocrinology, and with the National Reference Centers for Rare Mitochondrial Diseases, Neuro-Genetics, Neuro-Muscular Diseases , SLA, Huntington, Developmental Anomalies and Hormonal Receptivity, and the Memory Resource and Research Center.

Financial supports