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Mitochondrial and Cardiovascular Physiopathology | UMR Inserm U1083 - CNRS 6015

Separated by coma

Ion channels in vascular function

Christian Legros, Professor

 

 

christian.legros@univ-angers.fr

 

 

 

 

People involved in the project

  • Christian Legros, Ph.D. (Professor)
  • César Mattei, Ph.D. (Associate-Professor)
  • Hélène Tricoire, Ph.D. (Associate-Professor)
  • Claire Legendre, Ph.D (Associate-Professor)
  • Florian Beignon (Ph.D. Student)
  • Jacinthe Frangieh (Ph.D. Student)
  • Joohee Park (Ph.D. Student)
  • Léa Réthoré (Ph.D. Student)
  • Zineb Soualah (Ph.D. Student)

 

State of the art and objectives


Our group is interested in elucidating the role of voltage-gated sodium channels in the vascular function. We are currently working on different aspects of the cellular and molecular pharmacology of voltage-gated sodium channels (alkaloids, scorpion toxins…), the cell signalling they induce – particularly regarding the intracellular Ca2+ homeostasis – and their role in different cell types (endocrine cells, vascular endothelial cells…). Some of our projects also involve the pharmacological and physiological implication of GABA receptors and nicotinic acetylcholine receptors as key players of the vascular function and the regulation of the arterial blood pressure.

Project supported by

  • Région Pays de la Loire (pari scientifique SODIVASC 2017-2020, bourses de thèse Joohee Park et Florian Beignon)
  • DGA/MinDef (bourse de thèse 2018-2021 – Florian Beignon)
  • MESR (bourse de thèse 2019-2022 – Léa Rethoré)

Collaborations

  • Nathalie Guérineau, Arnaud Monteil (IGF Montpellier)
  • Antoine Taly (Institute of Physico-Chemical Biology, CNRS UPR9080, Paris)
  • Marc Verleye (Biocodex, Gentilly)
  • Benjamin Marie (Muséum National d’Histoire Naurelle)
  • Mireille Chinain (Institut Louis Mallardé, Polynésie française)
  • Jordi Molgó (CNRS-CEA Saclay)
  • Nathalie Arnich (ANSES Maisons-Alfort)
  • Andrea Bourdelais (Level 1 Fasteners, Wilmington, USA)

Selected recent articles


Review articles:

  •  Delcourt N, Lagrange E, Abadie E, Fessard V, Frémy JM, Vernoux JP, Peyrat MB, Maignien T, Arnich N, Molgó J, Mattei C (2019). Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health. Mar Drugs. 17(7): 425.
  •  Mattei C (2018). Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain? Mar Drugs. 16(2):72.
  •  Delcourt N, Claudepierre T, Maignien T, Arnich N, Mattei C (2017). Cellular and Molecular Aspects of the β-N-Methylamino-l-alanine (BMAA) Mode of Action within the Neurodegenerative Pathway: Facts and Controversy. Toxins (Basel). 10(1): 6.
  •  Pineau S, Legros C, Mattei C (2016). The Medical use of Lemon Balm (Melissa officinalis) and Valerian (Valeriana officinalis) as Natural Sedatives: Insight into their Interactions with GABA Transmission. Int J Clin Pharmacol Pharmacother. 1: 112.
  •  Hodson D, Legros C, Désarménien M, Guérineau NC (2015). Roles of connexins and pannexins in endocrine/neuroendocrine physiology. Cell Mol Life Sci 15:2911-28. doi: 10.1007/s00018.
  •  Mattei C, Legros C (2014). The voltage-gated sodium channel: a major target of marine neurotoxins. Toxicon 91:84-95.

Research articles:

  • Arnich N, Abadie E, Delcourt N, Fessard V, Fremy JM, Hort V, Lagrange E, Maignien T, Molgó J, Peyrat MB, Vernoux JP, Mattei C. (2020). Health risk assessment related to pinnatoxins in French shellfish. Toxicon. 180: 1-10.
  •  Mattei C, Taly A, Saulais O, Henrion H, Guérineau NC, Verleye M, Legros C* (2019). Involvement of the GABAA receptor alpha-subunit in the mode of action of etifoxine. Pharmacological Research. 145:104250.
  •  Frangieh J, Salma Y, Haddad K, Mattei C, Legros C, Fajloun Z, El Obeid D (2019). First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region. Toxins (Basel). 11(4). 191.
  •  Battault S, Meziat C, Nascimento A, Braud L, Gayrard S, Legros C, De Nardi F, Cazorla O, Drai J, Thireau J, Meyer G, and Reboul C (2018). Vascular endothelial function masks increased sympathetic vasopressor activity in rats with metabolic syndrome. Am J Physiol Heart Circ Physiol. H-00217-2017R1.
  •  De Nardi F, Lefort C, Bréard D, Richomme P, Legros C*, Guérineau NC* (2017). Monitoring the secretory behavior of the rat adrenal medulla by high-performance liquid chromatography-based catecholamine assay from slice supernatants. Front Endocrinol (Lausanne). 25;8:248.
  •  Khoury J, Dabbousya R, Riyad S, Antound S, Hleihele W, Legros C*, Fajloun Z* (2017). Evidence for in vitro antiophidian properties of aqueous buds extract of Eucalyptus against Montivipera bornmuelleri venom. J of Venom Res. 18;8:25-30.
  •  Crespin L, Legros C, List O, Tricoire-Leignel H, Mattei C (2016). Injection of insect membrane in Xenopus oocyte: an original method for the pharmacological characterization of neonicotinoid insecticides. J Pharmacol and Toxicol Meth 77:10-16.

 

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