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MitoVasc : physiopathologie cardiovasculaire et mitochondriale


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    Ion channels in vascular function

    Ion channels in vascular function

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    Christian Legros


    Team members : 

    • Christian Legros, Ph.D. (Professor)
    • César Mattei, Ph.D. (Assistant-Professor)
    • Hélène Tricoire, Ph.D. (Assistant-Professor)
    • Claire Legendre, Ph.D (Assistant-Professor)
    • Jacinthe Frangieh (Ph.D. Student)
    • Joohee Park (Ph.D. Student)
    • Zineb Soualah (Ph.D. Student)
    • Florian Beignon (Ph.D. Student)

     

    Our group is interested in elucidating the role of ion channels such as voltage-gated sodium channels in vascular function,. We are currently working on different aspects of the cellular and molecular pharmacology of voltage-gated sodium channels (alkaloids, scorpion toxins…) and their role in different cell types (endocrine cells, vascular endothelial cells…). Some of our projects also concern the pharmacology of GABA receptors and nicotinic acetylcholine receptors.

     


    Overview of ion channels in the vascular cells.
    CE: endothelial cells; CML: smooth muscle cell. TM: myogenic tone

     

    Last publications 

     

    • Mattei C, Taly A, Saulais O, Henrion H, Guérineau NC, Verleye M, Legros C* (2019). Involvement of the GABAA receptor -subunit in the mode of action of etifoxine. In press in Pharmacological Research. Vol. 145C.
    • Frangieh J, Salma Y, Haddad K, Mattei C, Legros C, Fajloun Z, El Obeid D (2019). First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region. Toxins (Basel). 11(4). 191.
    • Battault S, Meziat C, Nascimento A, Braud L, Gayrard S, Legros C, De Nardi F, Cazorla O, Drai J, Thireau J, Meyer G, and Reboul C (2018). Vascular endothelial function masks increased sympathetic vasopressor activity in rats with metabolic syndrome. Am J Physiol Heart Circ Physiol. H-00217-2017R1.
    • De Nardi F, Lefort C, Bréard D, Richomme P, Legros C*, Guérineau NC* (2017). Monitoring the Secretory Behavior of the Rat Adrenal Medulla by High-Performance Liquid Chromatography-Based Catecholamine Assay from Slice Supernatants. Front Endocrinol (Lausanne). 25;8:248.
    • Khoury J, Dabbousya R, Riyad S, Antound S, Hleihele W, Legros C*, Fajloun Z* (2017). Evidence for in vitro antiophidian properties of aqueous buds extract of Eucalyptus against Montivipera bornmuelleri venom. J of Venom Res. 18;8:25-30.
    • Crespin L, Legros C, List O, Tricoire-Leignel H, Mattei C (2016). Injection of insect membrane in Xenopus oocyte: an original method for the pharmacological characterization of neonicotinoid insecticides. J Pharmacol and Toxicol Meth 77:10-16.
    • Bourdin C, Guérineau NC, Quinchard S, Dong K, Legros C (2015). Molecular and functional characterization of a novel sodium channel TipE-like auxiliary subunit from the American cockroach Periplaneta americana. Insect Biochem Mol Biol 66:136-44. doi: 10.1016/j.ibmb.2015.10.008.
    • Vandael DH, Ottaviani MM, Legros C, Lefort C, Guérineau NC, Allio A, Carabelli V, Carbone E (2015): Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells. J Physiol 4:905-27. doi: 10.1113/jphysiol.2014.283374.
    • Legendre C, Avril S, Guillet C, Garcion E (2016). Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells. BMC Cancer. Feb 1;16:51. doi: 10.1186/s12885-016-2074-y.
    • Legendre C, Garcion E (2015). Iron metabolism: a double-edged sword in the resistance of glioblastoma to therapies. Trends Endocrinol Metab. Jun;26(6):322-31. doi: 10.1016/j.tem.2015.03.008. Review.
    • Abrieux A, Mhamdi A, Rabhi KK, Egon J, Debernard S, Duportets L, Tricoire-Leignel H, Anton S, Gadenne C. (2016) An Insecticide Further Enhances Experience-Dependent Increased Behavioural Responses to Sex Pheromone in a Pest Insect. PLoS ONE 11 (11): e0167469
    • Rabhi KK, Deisig N, Demondion E, Le Corre J, Robert G, Tricoire-Leignel H, Lucas P, Gadenne C, Anton S (2016). Low doses of a neonicotinoid insecticide modify pheromone response thresholds of central but not peripheral olfactory neurons in a pest insect. Proc Biol Sci. Feb 10;283(1824)
    • Rabhi KK, Esancy K, Voisin A, Crespin L, Le Corre J, Tricoire-Leignel H, Anton S, Gadenne C (2014). Unexpected effects of low doses of a neonicotinoid insecticide on behavioral responses to sex pheromone in a pest insect. PLoS One 9(12):e114411.
    • Taillebois E, Beloula A, Quinchard S, Jaubert-Possamai S, Daguin A, Servent D, Tagu D, Thany SH, Tricoire-Leignel H (2014) Neonicotinoid binding, toxicity and expression of nicotinic acetylcholine receptor subunits in the aphid Acyrthosiphon pisum. PLoS One, 9(5) e96669