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MitoVasc : physiopathologie cardiovasculaire et mitochondriale

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      Separated by coma
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    « MitoLab » Mitochondrial Pathophysiology

    Director G. Lenaers

    MitoLab is born from the convergence of mitochondrial physiology enthusiasts and the challenges posed by hereditary and common diseases involving mitochondrial dysfunction


    Created 20 years ago with the clinic and molecular diagnostic of Hereditary mitochondrial pathologies, our expertise and our technologic potential  have diversified with the will to build a continuum of research "bed to bed”, in the perspective of proposing new rational and efficient treatments.

    Three fundamental strategic and thematic orientations have been developed, focusing on:

    1) mitochondrial dynamics,

    2) maintaining the integrity of the mitochondrial genome,

    3) the metabolism of the mitochondria


    With hereditary and common associated  diseases:

    1) Dominant optic atrophy, Charcot Marie Tooth disease, encephalopathies, and myopathies, myocardial infarction, arterial hypertension,

    2) Mitochondrial DNA depletion syndromes, progressive external ophthalmoplegia and ovarian failure, intrauterine growth retardation,

    3) Leber Optic Neuropathy, MELAS, Leigh Syndrome and Glaucoma, DMLA, Myopia, Thyroid and Kidney Cancer, Sickle Cell Disease, Endometriosis, Forensic medicine.


    MitoLab is a team located at the interface between the University and the University Hospital Center of Angers, bringing together about fifty researchers, lecturer-researchers, doctors, engineers and technicians, post-doctoral and doctoral students, and students in Master and internal in medicine.

    The team involves the services of Biochemistry and Molecular Biology, Genetics, Ophthalmology Neurology and Reproductive Biology.

    It also interacts with the services of Gynecology-Obstetrics, Urology, Pediatrics, Internal and Forensic Medicine, Cardiology, Endocrinology, and with the National Reference Centers for Rare Diseases Mitochondrial Diseases, Neuro-Genetics, Neuro-Muscular Diseases , SLA, Huntington, Developmental Anomalies and Hormonal Receptivity, and the Memory Resource and Research Center.